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KMID : 0043319990220050348
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Archives of Pharmacal Research
1999 Volume.22 No. 5 p.348 ~ p.353
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Eudesmin Inhibits Tumor Necrosis Factor-α Production and T cell Proliferation
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Cho Jae-Youl
Yoo Eun-Sook
Baik Kyong-Up
Park Myung-Hwan
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Abstract
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Possible antiinflammatory effect of eudesmin were examined by assessing the effects on tumor necrosis factor (TNF)- production and lymphocyte proliferation as well as cytotoxicity against murine and human macrophages. the compound significantly inhibited TNF-, production by lipopolysaccaride (LPS)-stimulated murine macrophage RAW264.7 without displaying cytotoxicity suggesting that eudesmin may inhibit TNF- production without any interference of normal cell function. It also significantly attenuated T cell proliferation stimulated by concanavalin A (Con A) in a dose-dependent manner.
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KEYWORD
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Eudesmin, Magnolia fargessi, Tumor necrosis factor (TNF)-α, Lymphocyte proliferation
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